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KMID : 0356619920070010024
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Journal of Korean Society of Endocrinology
1992 Volume.7 No. 1 p.24 ~ p.30
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Expression of c-erb A mRNA According to Thyroid Function Status
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주영실
우정택/김성운/양인명/김진우/김영설/김광원/최영길/박상미
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Abstract
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To study whether thyroid hormone regulates triiodothyronine (T3) receptor at the gene level, total RNA was isolated from peripheral leukocytes in patients with hyperthyroidism and from the liver tissue of thyroxine induced hyperthyroid rat or
propylthiouracil induced hypothyroid rat. mRNA expression was examined by Northern hybridization technique using c-erb Aα complementary DNA probe.
C-erb A mRNA of approximately 2.0 kilobase size in length were expressed from peripheral leukocyte and from rat liver tissue. The degree of expression of c-erb A mRNA were negatively correlated with the level of thyroid hormone (T3 and T4
respectively)
in patients with hyperthyroidism. In rat liver tissue the c-erb A expression were increased in both hyperthyroid and hypothyroid status as compared to euthyroid status.
To explore the mechanism of biologic action of thyroid hormone, further studies to the relations between other c=-erb A gene and thyyroid hormone in various tissues will be needed. (J Kor Soc Endocrinol 7:24~30, 1992)
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KEYWORD
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